Latest Research on tumour suppressor : Jan 2022

Posted on January 17, 2022January 17, 2022Categories Cancer and TumorTags   Leave a comment on Latest Research on tumour suppressor : Jan 2022

The p53 tumour suppressor gene The cell cycle is composed of a series of steps which can be negatively or postively regulated by various factors. Chief among the negative regulators is the p53 protein. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumour viruses, can lead to cancer. These mutations seem to be the most common genetic change in human cancers.[1] Cytoplasmic functions of the tumour suppressor p53 The principal tumour-suppressor protein, … Continue reading “Latest Research on tumour suppressor : Jan 2022”

Latest Research on childhood cancer : Jan 2022

Posted on January 15, 2022January 15, 2022Categories Cancer and TumorTags   Leave a comment on Latest Research on childhood cancer : Jan 2022

Childhood cancer Background. Cancers of individual organs generally are composed of various histologic types, each with its own frequency and demographic patterns. For childhood cancers in particular, a classification of cancers by histologic type is important for understanding the etiology and progression of the disease. Methods. Data from the Surveillance, Epidemiology, and End Results (SEER) Program on 9308 microscopically confirmed malignant neoplasms in children younger than age 15, newly diagnosed during 1973-1987, were made available for analysis. Tumors were grouped … Continue reading “Latest Research on childhood cancer : Jan 2022”

Latest Research on endometrial cancer : Jan 2022

Posted on January 12, 2022January 12, 2022Categories Cancer and TumorTags   Leave a comment on Latest Research on endometrial cancer : Jan 2022

Endometrial Cancer The epidemiology, prevention, diagnosis, treatment, prognosis, and new International Federation of Gynecology and Obstetrics staging system of endometrial carcinoma are reviewed. Endometrial cancer has increased 21% in incidence since 2008, and the death rate has increased more than 100% over the past two decades. Precursor lesions of complex hyperplasia with atypia are associated with an endometrial carcinoma in more than 40% of cases. Endometrial cancer in white women occurs at twice the incidence as in black women, but, … Continue reading “Latest Research on endometrial cancer : Jan 2022”

Latest Research on Cancer Metastasis : Jan 2022

Posted on January 11, 2022January 11, 2022Categories Cancer and TumorTags   Leave a comment on Latest Research on Cancer Metastasis : Jan 2022

The pathogenesis of cancer metastasis Metastases do not result from random survival of cells released from the primary tumour but from the selective growth of specialised subpopulations of highly metastatic cells endowed with specific properties that befit them to complete each step of the metastatic process.[1] A Perspective on Cancer Cell Metastasis Metastasis causes most cancer deaths, yet this process remains one of the most enigmatic aspects of the disease. Building on new mechanistic insights emerging from recent research, we … Continue reading “Latest Research on Cancer Metastasis : Jan 2022”

Latest Research on Carcinosarcoma : Jan 2022

Posted on January 10, 2022January 10, 2022Categories Cancer and TumorTags   Leave a comment on Latest Research on Carcinosarcoma : Jan 2022

Carcinosarcoma The histologic classification of malignant tumors is important not only from an academic (histogenetic) standpoint, but also from that of prognosis and treatment. Thus the application and dosage of irradiation are primarily and principally dependent upon histologic detail, as is also the grading of malignant tumors. While ordinarily it is fairly well within the power of the pathologist to classify a malignant tumor, occasional growths are encountered which, despite obvious malignant features, cannot, because of their peculiar histologic detail, … Continue reading “Latest Research on Carcinosarcoma : Jan 2022”

Latest Research on Carcinosarcoma : Jan 2022

Posted on January 8, 2022January 8, 2022Categories Cancer and TumorTags   Leave a comment on Latest Research on Carcinosarcoma : Jan 2022

Carcinosarcoma The histologic classification of malignant tumors is important not only from an academic (histogenetic) standpoint, but also from that of prognosis and treatment. Thus the application and dosage of irradiation are primarily and principally dependent upon histologic detail, as is also the grading of malignant tumors. While ordinarily it is fairly well within the power of the pathologist to classify a malignant tumor, occasional growths are encountered which, despite obvious malignant features, cannot, because of their peculiar histologic detail, … Continue reading “Latest Research on Carcinosarcoma : Jan 2022”

Latest Research on Sarcoma : Jan 2022

Posted on January 7, 2022January 7, 2022Categories Cancer and TumorTags   Leave a comment on Latest Research on Sarcoma : Jan 2022

Mechanisms of sarcoma development Sarcomas are a rare and diverse group of tumours that are derived from connective tissues, including bone, muscle and cartilage. Although there are instances of hereditary predisposition to sarcomas, the overwhelming majority of such tumours are sporadic. In the past decade, we have gained much insight into the genetic abnormalities that seem to underlie the pathogenesis of these tumours. This information has already led to new classification of many sarcomas, as well as to successful therapies … Continue reading “Latest Research on Sarcoma : Jan 2022”

Latest Research on tumor : Jan 2022

Posted on January 6, 2022January 6, 2022Categories Cancer and Tumor   Leave a comment on Latest Research on tumor : Jan 2022

The tumor microenvironment and its role in promoting tumor growth The tumor microenvironment is created by the tumor and dominated by tumor-induced interactions. Although various immune effector cells are recruited to the tumor site, their anti-tumor functions are downregulated, largely in response to tumor-derived signals. Infiltrates of inflammatory cells present in human tumors are chronic in nature and are enriched in regulatory T cells (Treg) as well as myeloid suppressor cells (MSC). Immune cells in the tumor microenvironment not only … Continue reading “Latest Research on tumor : Jan 2022”

Latest Research on Neck Cancer: Jan 2021

Posted on January 21, 2021Categories Cancer and TumorTags   Leave a comment on Latest Research on Neck Cancer: Jan 2021

Head and neck cancer: past, present and future Head and neck cancer consists of a diverse group of cancers that ranges from cutaneous, lip, salivary glands, sinuses, oral cavity, pharynx and larynx. Each group dictates different management. In this review, the primary focus is on head and neck squamous cell carcinoma (HNSCC) arising from the mucosal lining of the oral cavity and pharynx, excluding nasopharyngeal cancer. Presently, HNSCC is the sixth most prevalent neoplasm in the world, with approximately 900,000 … Continue reading “Latest Research on Neck Cancer: Jan 2021”

Latest Research on Gallbladder Cancer : Dec 2020

Posted on December 4, 2020December 26, 2020Categories Cancer and TumorTags   Leave a comment on Latest Research on Gallbladder Cancer : Dec 2020

Gallbladder cancer Background Gallbladder cancer (GC) is a relatively rare but highly lethal neoplasm. We review the epidemiology, etiology, pathology, symptoms, diagnosis, staging, treatment, and prognosis of GC. Method A Pubmed database search between 1971 and February 2007 was performed. All abstracts were reviewed and articles with GC obtained; further references were extracted by hand-searching the bibliography. The database search was done in the English language. Results The accurate etiology of GC remains unclear, while the symptoms associated with primary … Continue reading “Latest Research on Gallbladder Cancer : Dec 2020”