Coagulation and Bleeding Disorders: Review and Update Hemostasis is initiated by injury to the vascular wall, leading to the deposition of platelets adhering to components of the subendothelium. Platelet adhesion requires the presence of von Willebrand factor and platelet receptors (IIb/IIIa and Ib/IX). Additional platelets are recruited to the site of injury by release of platelet granular contents, including ADP. The “platelet plug” is stabilized by interaction with fibrinogen. In this review, I consider laboratory tests used to evaluate coagulation, … Continue reading “Latest Research on bleeding disorders : Jan 2022”
Latest Research on hematological malignancies : Jan 2022
Posted on January 4, 2022January 4, 2022Categories Blood Leave a comment on Latest Research on hematological malignancies : Jan 2022Nanomedicines for the treatment of hematological malignancies Hematological malignancies (HM) are a collection of malignant transformations originating from cells in the primary or secondary lymphoid organs. Leukemia, lymphoma, and multiple myeloma comprise the three major types of HM. Current treatment consists of bone marrow transplantation, radiotherapy, immunotherapy and chemotherapy. Although, many chemotherapeutic drugs are clinically available for the treatment of HM, the use of these agents is limited due to dose-related toxicity and lack of specificity to tumor tissue. Moreover, … Continue reading “Latest Research on hematological malignancies : Jan 2022”
Latest Research on blood disorders : Jan 2022
Posted on January 3, 2022January 3, 2022Categories Blood Leave a comment on Latest Research on blood disorders : Jan 2022Genetic Blood Disorders Survey in the Sultanate of Oman The Genetic Blood Disorders Survey is the first community-based survey in the Arabic world and the Middle East to determine the prevalence of the most common genetic blood disorders. The objective of the survey was to determine the prevalence of the most common genetic blood disorders reported among Omani children under 5 years of age in order to provide the planners and policy-makers with reliable information suitable for formulating health policies, … Continue reading “Latest Research on blood disorders : Jan 2022”
Latest Research on promyelocytic leukemia : Jan 2022
Posted on January 1, 2022January 1, 2022Categories Blood Leave a comment on Latest Research on promyelocytic leukemia : Jan 2022How I treat acute promyelocytic leukemia Acute promyelocytic leukemia is the first malignant disease highly curable with targeted therapy directed at a unique molecular abnormality. The characteristic bleeding diathesis is the most notorious manifestation of the disease, which historically has accounted for a high mortality rate during induction. Acute promyelocytic leukemia is one of the few hematologic diseases that must be recognized under the microscope by the practicing hematologist because early institution of all-trans retinoic acid (ATRA) at the first … Continue reading “Latest Research on promyelocytic leukemia : Jan 2022”
Latest Research on Blood Cancer : Dec 2021
Posted on December 31, 2021December 31, 2021Categories Blood Leave a comment on Latest Research on Blood Cancer : Dec 2021Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence BACKGROUNDCancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent. METHODSWe analyzed data from whole-exome sequencing of DNA in peripheral-blood cells from 12,380 persons, unselected for cancer or hematologic phenotypes. We identified somatic mutations on the basis of unusual allelic fractions. We used data from Swedish national patient registers to follow health outcomes for … Continue reading “Latest Research on Blood Cancer : Dec 2021”
Latest Research on blood vessel : Dec 2021
Posted on December 30, 2021December 30, 2021Categories Blood Leave a comment on Latest Research on blood vessel : Dec 2021Vascular-specific growth factors and blood vessel formation A recent explosion in newly discovered vascular growth factors has coincided with exploitation of powerful new genetic approaches for studying vascular development. An emerging rule is that all of these factors must be used in perfect harmony to form functional vessels. These new findings also demand re-evaluation of therapeutic efforts aimed at regulating blood vessel growth in ischaemia, cancer and other pathological settings.[1] Significance of Blood Vessel Leakiness in Cancer Despite major advances … Continue reading “Latest Research on blood vessel : Dec 2021”
Latest Research on ABO Blood : Nov 2020
Posted on November 25, 2020Categories Blood Leave a comment on Latest Research on ABO Blood : Nov 2020ABO Blood Group and the Risk of Pancreatic Cancer Background Other than several rare, highly penetrant familial syndromes, genetic risk factors for sporadic pancreatic cancer are largely unknown. ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies. Methods We separately examined the relationship between ABO blood type and the risk of incident pancreatic cancer in two large, independent, prospective cohort studies (the Nurses’ Health Study and Health Professionals … Continue reading “Latest Research on ABO Blood : Nov 2020”
Latest Research on Myelofibrosis : Nov 2020
Posted on November 24, 2020Categories Blood Leave a comment on Latest Research on Myelofibrosis : Nov 2020New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment Therapeutic decision-making in primary myelofibrosis (PMF) is becoming more challenging because of the increasing use of allogeneic stem cell transplantation and new investigational drugs. To enhance this process by developing a highly discriminative prognostic system, 1054 patients consecutively diagnosed with PMF at 7 centers were studied. Overall median survival was 69 months (95% confidence interval [CI]: 61-76). Multivariate analysis … Continue reading “Latest Research on Myelofibrosis : Nov 2020”
News Update on Anemia Research: Jan – 2020
Posted on January 31, 2020Categories Blood Leave a comment on News Update on Anemia Research: Jan – 2020Anemia of Chronic Disease New therapeutic strategies have emerged along side our understanding that disturbances of iron homeostasis, impaired proliferation of erythroid progenitor cells, and blunted erythropoietin response occur in anemia of chronic disease. This review discusses advances in our knowledge of the causes and management of the condition. [1] Autoimmune hemolytic anemia Red blood corpuscle (RBC) autoantibodies are a comparatively uncommon explanation for anemia. However, autoimmune haemolytic anaemia (AIHA) must be considered within the medical diagnosis of hemolytic anemias, … Continue reading “News Update on Anemia Research: Jan – 2020”
Latest Research News on Bone Marrow: Jan – 2020
Posted on January 28, 2020Categories Blood Leave a comment on Latest Research News on Bone Marrow: Jan – 2020Osteogenesis in transplants of bone marrow cells After heterotopic (e.g. subcutaneous) transplantation of bone marrow, haemopoiesis within the graft ceases; reticular tissue develops instead, and later bone is made (Denis, 1958). The result are often achieved by grafting either free pieces of bone marrow or those placed in diffusion chambers (Petrakova, Tolmacheva & Friedenstein, 1963; Rosin, Freiberg & Sajnek, 1963). within the case of free transplantation the bone formed is later crammed with bone marrow. After transplantation in diffusion chambers … Continue reading “Latest Research News on Bone Marrow: Jan – 2020”