Category: Biochemistry

The lipocalin protein family: structure and function The lipocalin protein family is a large group of small extracellular proteins. The family demonstrates great diversity at the sequence level; however, most lipocalins share three characteristic conserved sequence motifs, the kernel lipocalins, while a group of more divergent family members, the outlier lipocalins, share only one. Belying this sequence dissimilarity, lipocalin crystal structures are highly conserved and comprise a single eight-stranded continuously hydrogen-bonded antiparallel β-barrel, which encloses an internal ligand-binding site. Together … Continue reading “Latest Research on Lipocalin : Dec 2021”

Postprandial lipemia and cardiovascular disease Postprandial lipemia, characterized by a rise in triglyceride-rich lipoproteins after eating, is a dynamic, nonsteady-state condition in which humans spend the majority of time. There are several lines of evidence suggesting that postprandial lipemia increases risk of atherogenesis. Clinical data show a correlation between postprandial lipoproteins and the presence/progression of coronary artery disease and carotid intimal thickness. Mechanistic studies demonstrate that triglyceride-rich lipoprotein remnants may have adverse effects on endothelium and can penetrate into the … Continue reading “Latest Research on Lipemia : Dec 2021”

Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study The ulcer protective potential of methanolic extract of Emblica officinalis Gaertn. (EOE) was assessed in different acute gastric ulcer models in rats induced by aspirin, ethanol, cold restraint stress and pyloric ligation and healing effect in chronic gastric ulcers induced by acetic acid in rats. EOE, 10–50 mg/kg administered orally, twice daily for 5 days showed dose-dependent ulcer protective effects in all the above acute ulcer models (36.0–98.3% protection, … Continue reading “Latest Research on Methanolic Extract : Dec 2021”

Denaturing high-performance liquid chromatography: A review Denaturing high-performance liquid chromatography (DHPLC) compares two or more chromosomes as a mixture of denatured and reannealed PCR amplicons, revealing the presence of a mutation by the differential retention of homo- and heteroduplex DNA on reversed-phase chromatography supports under partial denaturation. Temperature determines sensitivity, and its optimum can be predicted by computation. Single-nucleotide substitutions, deletions, and insertions have been detected successfully by on-line UV or fluorescence monitoring within 2–3 minutes in unpurified amplicons as … Continue reading “Latest Research on High Performance Liquid Chromatography : Dec 2021”

IMPROVING THE NUTRIENT COMPOSITION OF PLANTS TO ENHANCE HUMAN NUTRITION AND HEALTH Plant foods contain almost all of the mineral and organic nutrients established as essential for human nutrition, as well as a number of unique organic phytochemicals that have been linked to the promotion of good health. Because the concentrations of many of these dietary constituents are often low in edible plant sources, research is under way to understand the physiological, biochemical, and molecular mechanisms that contribute to their … Continue reading “Latest Research on Nutrient Composition : Dec 2021”

Human Fatty Liver Disease: Old Questions and New Insights Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries. The disease begins with the aberrant accumulation of triglyceride in the liver, which in some individuals elicits an inflammatory response that can progress to cirrhosis and liver cancer. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood, and therapeutic options are … Continue reading “Latest Research on Fatty Liver : Dec 2021”

Electric-field-induced superconductivity at 9.4 K in a layered transition metal disulphide MoS2 Electro-static carrier doping was attempted in a layered transition metal disulphide MoS2 by constructing an electric double-layer transistor with an ionic liquid. With the application of gate voltage VG higher than 3 V, a metallic behavior was observed in the MoS2 channel. We found an onset of electric field-induced superconductivity in the field induced metallic phase. A maximum TC ∼ 9.4 K was observed, which could be higher than those in chemically doped … Continue reading “Latest Research on Disulphide : Dec 2021”