SYNTHESIS, CHARACTERIZATION AND ANTIFUNGAL, ANTIBACTERIAL STUDIES OF HYDRAZONE-OXIME METAL COMPLEXES
A new oxime ligand, H2L (C13H18N4O2) was synthesized by the condensation of alcoholic solutions of hydrazide compound and acetyl monoxime. The seven coordination compounds, [(HL)Co2(OAc)2(H2O)4], [(HL)Mn(OAc)(H2O)], [(HL)Zn(OAc)(H2O)], [(HL)Ni(OAc)(H2O)], [(HL)RuCl2(H2O)], [(HL)Fe2Cl4(H2O)3] and [(H2L)2UO2(NO3)2] have been synthesized by reacting Co(II), Mn(II), Zn(II), Ni(II), Ru(III ), Fe(III) and UO2(II) ions with the ligand. The complexes have been isolated in solid state and characterized by elemental (C, H, N) analysis, magnetic susceptibility measurements, spectral (UV-Visible, IR, 1H and 13C NMR), thermal analysis and molar conductivity. A tentative structure for these complexes were proposed and suggested in which coordination numbers were six around Co(II), Mn(II), Zn(II), Ni(II), Ru(III) and Fe(III) metal ions whereas was eight in the case UO2(II) ion. Elemental analyses, stoichiometric and spectroscopic data of the metal complexes indicated that the metal: Ligand ratio of Co(II) and Fe(III) complexes were found to be 2M:1L while this ratio was 1:1 in Mn(II), Zn(II), Ni(II) and Ru(III) complexes and 1:2 in UO2(II) complex. Finally, the ligand and its complexes were assessed for their bioactivity.
COMPUTATIONAL AND SPECTROSCOPIC CHARACTERIZATIONS OF SOME N-ALKYL (BENZYL)-DIAZENIUM DIOLATES AND THEIR METAL COMPLEXES
The molecular and electronic structures and spectroscopic characteristics of a series of N-alkyl(benzyl)-N-nitroso hydroxylaminesat deprotonation (diazenium diolates) and complex formation were studied by computational (DFT/ B3LYP) and spectroscopic (UV-VIS) methods. Molecular and electronic structures as well as the bond character in the complexes with the metal ions of various natures are described. The results of the DFT calculations do not contradict the crystal structure determination data and the spectral characteristics of the complexes.
Synthesis and Characterization of Metal Complexes of Derivative of 1,10-phenanthroline
Mononuclear complexes of Zn(II) N,N’ coordinated with phendione and phendioxime and polynuclear of Ni(II), Cu(II) and Zn(II) complexes of the phendioxime were synthesized and characterized by direct and template method. Ni(II), Cu(II) and Zn(II) species coordinated by N,N’ of the oximate and phen groups, Ni(II) complex of the oximate has square-planar geometry and phen has octahedral geometry whereas; Cu(II) and Zn(II) complexes of oximate and phen have octahedral geometry. Mononuclear complex of Zn(II) with phendione N,N’ coordinated was precursor for mononuclear complex of Zn(II) with phedioxime N,N’ octahedral coordinated by phen group and heteronuclear complex of Ni(II) with mononuclear Zn-phendioxime complex was synthesized and characterized by template method. Zn(II) and Ni(II) species coordinated by N,N’ of phen and oximate groups, respectively. Zn(II) moiety coordinated through N,N’ of phen has octahedral geometry and Ni(II) moiety coordinated through N,N’ of oximate has tetrahedral geometry. Structures of the ligand and its complex are suggested and formulated according to the elemental analysis, 1H, 13C NMR, UV-Vis, IR, AAS, molar conductivity and magnetic susceptibility.
Mutagenic Effects of Some Metal Complexes I. Cytotoxic Activity of Bis (L-glutaminato) Tetrachloropalladate (II)
The tetrachloropalladate (II) complex salt which with glutamine of formula [(Pd Cl4) H2. (L- Glutamine)2], was prepared and characterized through IR spectroscopy. The compound was found cytotoxic to TA 98 bacterial cells of Salmonella typhimurium. To our knowledge this is the first anionic Pd complex salt of L-glutamine exhibiting potential cytotoxic activity.