Press Release on Zika Virus Research: September-2018

In Test With Mice, Zika Virus Eliminates Human Brain Tumor Common In Children

A study revealed within the journal Cancer analysis, of the yank Association for Cancer analysis, reveals the therapeutic aspect of the Zika virus, that in 2015 created international public health authorities cautious once the link between the infection of the virus throughout gestation and therefore the birth of kids with microcephalus was established.

Now, Brazilian researchers at the middle for Human ordination and somatic cell Studies at the University of city have place the virus to sensible use showing, for the primary time in animals, the hurtful result of the injection of a coffee concentration of the pure virus on human embryonic brain tumors induced  in mice with low immunity. [1]

Antiviral phytocompounds target envelop protein to control Zika virus

Zika infection causes serious birth defects, together with nanocephaly, once expectant mothers area unit infected throughout maternity. Zika outbreaks are reportable within the Pacific Islands, South America, the Caribbean, Africa and elements of South East Asia. Currently, there’s no specific treatment out there for Zika infection. Hence, this study is targeted to spot natural phytocompounds to regulate Zika virus from few endemic anti-viral herbs by in silico approach. Molecular interactions, Pharmacokinetic Study, Molecular dynamic simulation and hardening were dole out with the phytocompounds and checked victimization Lipinski filter. The interactions between the phytocompounds and Envelope macromolecule (PDB id: 5JHM) of Zika virus was assessed with SYBYL-X one.3. [2]

Disruption of RNA Metabolism by Zika Virus

Flaviviruses area unit positive, fiber, engulfed ribonucleic acid viruses that area unit a section of the family, arbovirus. West Nile River virus, Dengue, Zika virus and a lot of area unit a section of this family. Mosquitoes area unit the vectors for these viruses. so as for the virus to infect mosquitoes, it should evade the ribonucleic acid interference (RNAi), that is that the major antiviral immune mechanism of insects. One study found the 3’ untranslated region (UTR) of the West Nile River virus that restrained the RNAi (GP et al. 2016). The goal of this study is to research if the 3’ and 5’ UTR region of the Zika virus (ZIKV) inhibits the RNAi still. [3]

The Effect of Permethrin Resistance on Aedes aegypti Transcriptome Following Ingestion of Zika Virus Infected Blood

Aedes aegypti (L.) is that the primary vector of the many rising arboviruses. pesticide resistance among dipteran populations may be a consequence of the applying of pesticides for dipteran management. we have a tendency to used RNA-sequencing to check transcriptomes between permethrin resistant and inclined strains of FL Ae. aegypti in response to Zika viral infection. a complete of 2459 transcripts were expressed at considerably totally different levels between resistant and inclined Ae. Egypt. factor metaphysics analysis placed these genes into seven classes of biological processes. The 863 transcripts were expressed at considerably totally different levels between the 2 dipteran strains (up/down-regulated) over 2-fold. Quantitative time period PCR analysis was accustomed validate the Zika-infection response. Our results advised a extremely overexpressed P450, with AAEL014617 and AAEL006798 as potential candidates for the molecular mechanism of permethrin resistance in Ae. Egypt. [4]

Stability Analysis of Deterministic Mathematical Model for Zika Virus

This analysis paper presents the soundness analysis of infectious state of Zika Virus in many varieties of population in mathematical perspective. This model specializes in infectious agent activity in illness free equilibrium, in epidemic equilibrium and their R0 of epidemic below the likelihood of unfold because of human interaction. [5]

Reference

[1] In Test With Mice, Zika Virus Eliminates Human Brain Tumor Common In Children

April 26, 2018 (web link)

[2] Antiviral phytocompounds target envelop protein to control Zika virus

Priya S, Kumar NS, Hemalatha S. Antiviral phytocompounds target envelop protein to control Zika virus. Computational Biology and Chemistry. 2018 Aug 29. (web link)

[3] Disruption of RNA Metabolism by Zika Virus

Dickerson ML. Disruption of RNA Metabolism by Zika Virus. (web link)

[4] The Effect of Permethrin Resistance on Aedes aegypti Transcriptome Following Ingestion of Zika Virus Infected Blood

Zhao L, Alto B, Shin D, Yu F. The Effect of Permethrin Resistance on Aedes aegypti Transcriptome Following Ingestion of Zika Virus Infected Blood. Viruses. 2018 Sep 1;10(9):470. (web link)

[5] Stability Analysis of Deterministic Mathematical Model for Zika Virus

  1. Khalid1* and Fareeha Sami Khan1

1Department of Mathematical Sciences, Federal Urdu University of Arts, Sciences & Technology, Karachi, Pakistan. (web link)

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