Press Release on Sjogren Syndrome Research: September-2018

Sjögren’s Syndrome significantly increases risk of heart attack

A new study given these days at the eu League Against Rheumatism Annual Congress (EULAR 2014) showed a considerably raised risk of attack in patients with Sjögren’s syndrome (SjS), notably within the initial year following designation. There was additionally a trend towards associate degree raised risk for stroke.

SjS is associate degree auto-immune disease wherever the body’s system attacks glands that secrete fluid, appreciate the tear and spit glands. Inflammation within the glands reduces fluid production inflicting painful burning within the eyes, dry mouth, and generally waterlessness within the nasal passages, throat, channel and skin. [1]

 

FRI0358 Factors associated with pulmonary manifestations in sjogren syndrome

Background Primary Sjögren’s Syndrome (pSS) may be a general disease defined by leucocyte infiltration of the gland glands leading to dry syndrome. some third of patients have extraglandular general findings, similar to metabolic process symptoms (43%–75%), that are thought of to be a reason behind morbidity and learning quality of life. The aim of the study is to estimate the prevalence of respiratory organ manifestations in pSS, and to spot factors related to its development.

Methods SJOGREN-SER (Spanish medical specialty Society written account of pSS) may be a multicenter cross-sectional study of pSS patients beneath active follow-up at thirty three medical specialty departments through European country. Patients fullfilled the European-American agreement criteria of 2002. Airway malady (dry cough, xerotrachea, bronchial, hyperresponsiveness and airway obstruction) and respiratory organ involvement (ILD, respiratory organ illness, respiratory organ blood vessel cardiovascular disease, redness and serosa involvement) were thought of in line with the definition contained in EULAR Sjögren’s malady Activity Index (ESSDAI), further as Sjögren’s Syndrome malady harm Index. [2]

 

Otorhinolaryngological Manifestations in Sjogren Syndrome

Background: Sjögren’s Syndrome (SS) is that the second commonest response rheumatic illness once rheumatism and affects some one to 3 of the population. Most patients full of Sjogren’s syndrome manifest otorhinolaryngological involvement, love organ, ocular, oral, otological, pharyngeal, organ and sinonasal symptoms.Objective: The aim of this text is to stress the otorhinolaryngological manifestations of SS. Since otorhinolaryngologists area unit typically the primary practitioners to discover the symptoms, an entire and careful ENT examination ought to be performed altogether the patients suspected to own this syndrome. [3]

 

Prevalence of Novel Candidate Sjogren Syndrome Autoantibodies in the Dry Eye Assessment and Management (DREAM) Study

Purpose: to judge the prevalence of novel candidate Sjogren syndrome (SS) autoantibodies [salivary protein-1 (SP-1), salivary gland humor macromolecule, carbonaceous anhydrase 6] within the DRy Eye Assessment and Management (DREAM) cohort, a study evaluating the effectiveness of omega-3 fatty acid carboxylic acid supplements for the treatment of dry eye.

Methods: Participants underwent ocular surface examinations and serologic testing for ancient and novel SS autoantibodies. Dry eye assessment and management participants were classified into the subsequent three groups: 1) no history of SS or different response diseases and negative ancient SS autoantibodies (n = 352); 2) no history of SS however a history of different response diseases (n = 66); and 3) people who met the 2012 yankee faculty of medical specialty SS classification criteria (n = 52). [4]

 

Clinical and Serological Features of Sjogren Syndrome in Patients with Rheumatoid Arthritis

Background: it’s unsure whether or not the Sjogren Syndrome (SS) related to autoimmune disease (RA) represents a clinical entity like primary SS (pSS) or just a manifestation within the clinical spectrum of RA. within the gift study, we have a tendency to sought-after to work out the clinic and serological options of SS related to RA compared to the RA options victimisation well outlined SS classification criteria.

Methods: RA patients in turn referred for a life infusion were questioned on oral and ocular status. Schirmer’s check and unstimulated secretion flow were performed in every patient. Patients with subjective oral or ocular status and/or one abnormal objective check underwent a minor exocrine gland diagnostic test. The identification of secondary SS was supported the standards of European-American agreement cluster criteria for SS. Clinical and biological parameters of SS and RA (with live of sickness activity and health standing of RA, seek for Raynaud’s development, anti-CCP, RF anti-SSA-positivity and beta2-microglobulin level) were then compared between patients with/without Selective Service System [5]

Reference

[1] Sjögren’s Syndrome significantly increases risk of heart attack

Date: June 13, 2014, Source: European League Against Rheumatism (web link)

[2] FRI0358 Factors associated with pulmonary manifestations in sjogren syndrome

Judez E, Sanchez-Piedra C, Castro MF, Andreu JL, Rosas J, Taboada VM, Olivé A. FRI0358 Factors associated with pulmonary manifestations in sjogren syndrome. (web link)

[3] Otorhinolaryngological Manifestations in Sjogren Syndrome

Angeletti D, Iannella G, Ciofalo A, Re M, Plateroti R, Plateroti P, Pasquariello B, Manno A, Didona D, Magliulo G. Otorhinolaryngological Manifestations in Sjogren Syndrome. Current Immunology Reviews. 2018 Apr 1;14(1):24-30. (web link)

[4] Prevalence of Novel Candidate Sjogren Syndrome Autoantibodies in the Dry Eye Assessment and Management (DREAM) Study

Bunya VY, Ying GS, Maguire MG, Kuklinski E, Lin MC, Peskin E, Asbell PA, DREAM Study Research Group. Prevalence of Novel Candidate Sjogren Syndrome Autoantibodies in the Dry Eye Assessment and Management (DREAM) Study. Cornea. 2018 Aug 29. (web link)

[5] Clinical and Serological Features of Sjogren Syndrome in Patients with Rheumatoid Arthritis

Kaouther Ben Abdelghani1, Ines Mahmoud1*, Emanuel Chatelus1, Christelle Sordet1, Jacques Eric Gottenberg1 and Jean Sibilia1

1Rheumatology Department, Hautepierre Hospital, 1, Molière Avenue, 67000 Strasbourg, France. (web link)

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