Press Release on Schizophrenia Research: September-2018

People With Schizophrenia Account For More Than One In 10 Suicide Cases

A new CAMH and Institute for Clinical appraising Sciences (ICES) study shows that individuals with schizophrenic psychosis account for quite one in ten cases of suicide in Ontario, which adolescents area unit disproportionately affected.

“Among those that died by suicide, having an identification of schizophrenic psychosis is clearly over-represented,” says Dr. Juveria Zaheer, 1st author, and practician somebody in CAMH’s Institute for psychological state Policy analysis. [1]

Schizophrenia in type 2 diabetes mellitus: Prevalence and clinical characteristics

Background: This study investigated the prevalence and characteristics of psychosis in patients with kind a pair of diabetes (T2DM) in Taiwan.

Methods: National insurance claims information for patients with principal diagnoses of psychosis and T2DM were analyzed.

Results: Compared with patients with psychosis within the general population (GP), those with psychosis and T2DM were additional probably to own higher Charlson comorbidity index (CCI) scores and multiple comorbidities, and were older. [2]

Symptoms Specific to Schizophrenia

Symptoms specific to psychosis embody self-disturbances, neurotic perception and loosening of associations. Self-disturbances in psychosis may be explained from the stand of AN abnormal sense of agency, admire thought broadcasting as AN over-attribution of agency ANd thought insertion as an under-attribution of the agency. [3]

Activation of brainstem and midbrain nuclei during cognitive control in medicated patients with schizophrenia

Evidence suggests that psychological feature management functions still because of the underlying brain network, anchored by the anterior cortex (PFC) and therefore the dorsal anterior cingulate cortex (dACC), square measure dysfunctional in psychosis. hormone manufacturing neural structure and neural structure nuclei square measure densely connected with the greenhouse emission and dACC and exert profound contributions to psychological feature management processes. Dysfunctions within the underlying neurochemical systems square measure thought of to play a central role within the incidence of assorted symptoms of psychosis. we have a tendency to wanted to research the putatively abnormal activation pattern of the dopaminergic neural structure nuclei, that is, ventral tegmental space (VTA) and locus niger still as that of the noradrenergic locus coeruleus (LC) in patients with psychosis throughout psychological feature management. A total of 28 medicated patients and 27 healthy controls were investigated with the manual version of the Stroop task using event‐related fMRI. [4]

AUGMENTING CLOZAPINE NON-RESPONSE IN SCHIZOPHRENIA WITH PSYCHOSOCIAL INTERVENTIONS: LESSONS FROM A PATIENT SERIES

Aims: concerning four-hundredth to seventieth of patients with treatment-resistant psychosis respond inadequately to Clozaril. Augmentation with alternative medications or shock therapy confers little or no profit in Clozaril non-response. analysis of augmentation with psychosocial treatments in clozapine-resistance is restricted, however, shows some promise. the advantages of psychosocial interventions in augmenting Clozaril-response square measure highlighted by the treatment histories of 3 patients with treatment-resistant psychosis UN agency responded poorly to clozapine. [5]

Reference

[1] People With Schizophrenia Account For More Than One In 10 Suicide Cases

June 23, 2018 (web link)

[2] Schizophrenia in type 2 diabetes mellitus: Prevalence and clinical characteristics

Huang CJ, Hsieh HM, Tu HP, Jiang HJ, Wang PW, Lin CH. Schizophrenia in type 2 diabetes mellitus: Prevalence and clinical characteristics. European Psychiatry. 2018 Oct 1;54:102-8. (web link)

[3] Symptoms Specific to Schizophrenia

Funayama M. Symptoms Specific to Schizophrenia. Brain and nerve= Shinkei kenkyu no shine. 2018 Sep;70(9):981-91. (web link)

[4] Activation of brainstem and midbrain nuclei during cognitive control in medicated patients with schizophrenia

Köhler S, Wagner G, Bär KJ. Activation of brainstem and midbrain nuclei during cognitive control in medicated patients with schizophrenia. Human Brain Mapping. (web link)

[5] AUGMENTING CLOZAPINE NON-RESPONSE IN SCHIZOPHRENIA WITH PSYCHOSOCIAL INTERVENTIONS: LESSONS FROM A PATIENT SERIES

VIJAYA LAKSHMI VALAPARLA1, VANDANA PATIDAR1, AND SUBHO CHAKRABARTI1*

1Department of Psychiatry, Postgraduate Institution of Medical Education and Research (PGIMER), Chandigarh 160012, India. (web link)

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