Newsletter on Celiac Disease Research: September-2018

Looking for an off switch for celiac disease

Celiac disease is associate degree autoimmune disease that affects by some estimates nearly one in one hundred folks. upset symptoms are triggered by protein, a macromolecule found in wheat and connected plants, however protein does not act alone to cause the biological process symptoms that patients suffer. Rather, protein induces associate degree active immune reaction once it’s changed by the accelerator transglutaminase a pair of, or TG2, within the bowel. New analysis printed within the Gregorian calendar month. twenty-three issue of the Journal of Biological Chemistry identifies associate degree accelerator that turns off TG2, doubtless paving the manner for brand spanking new treatments for an upset. [1]

Oral Manifestations of Celiac Disease and Wheat Allergy: Report of Three Cases and Review of Literature

Celiac Disease (CD) is AN immune-mediated general sickness, caused by protein and connected prolamins, in genetically prone people. it’s characterized by gluten-dependent clinical manifestations, CD-specific antibodies, HLA DQ2 or DQ8 haplotypes, and disease. Most patients square measure well or with delicate manifestations. It primarily affects the systema alimentarium inflicting symptoms and signs comparable to the looseness of the bowels, continuous abdominal pain, and abdominal distension; additionally extra digestive manifestations. Patients with CD might have oral manifestations that embody continual aphthous redness (RAS), enamel dysplasia, symptom rubor, among others. [2]

Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study

Objective: Microscopic inflammatory bowel disease may be a common explanation for chronic watery symptom among the older. though the prevalence of upset seems to be higher in patients with microscopic inflammatory bowel disease, the connection between dietary protein intake and risk of microscopic inflammatory bowel disease among people while not upset has not been explored.

Methods: we tend to conduct a prospective study of a hundred and sixty,744 North American country ladies while not upset registered within the Nurses’ Health Study (NHS) and also the NHSII. Dietary protein intake was calculable victimization valid food frequency questionnaires every four years. Microscopic inflammatory bowel disease was confirmed through medical records review. we tend to used Cox proportional hazard modeling to estimate the multivariable-adjusted hazard quantitative relation (HR) and ninety-fifth confidence interval (CI). [3]

The Nutritional and Social Contexts of Celiac Disease in Women: A Qualitative Study.

Previous studies have confirmed that ladies WHO area unit diagnosed with disorder report a lower quality of life than men WHO area unit diagnosed with an equivalent health problem. This article describes the life experiences of girls with the disorder, particularly those that adhere to a womb-to-tomb diet. A phenomenological style supported the Giorgi technique was used. Twenty-two ladies WHO were diagnosed with the disorder and were between sixteen and seventy-five years previous completed the semistructured interviews. The results showed that disorder has differing effects on the lives of girls sufferers. the final feeling of being a lady with the disorder was represented as an endeavor toward achieving a normalized life. [4]

PHARMACOGENOMICS OPEN A NEW GATEWAY IN THE TREATMENT OF CELIAC DISEASE

Background: AN immune mediate disease upset (CD) is AN automotive vehicle immune disease that happens because of harm to the liner of the tiny internal organ once foods with protein square measure eaten. upset is characterized by system biological process issues, a severe rash referred to as eczema, herpetiformis, iron deficiency anemia (low blood count), growth issues and failure to thrive (in children), Seizures, Aphthous ulcers, tingling sensation within the legs.

Objective: Our goal is to emphasize on the treatment confusion because of misjudgment with upset and irritable gut syndrome and its treatment that become potential not solely by the utilization of protein-free diet however also can be treated by rising field of pharmacogenomics technology. [5]

Reference

[1] Looking for an off switch for celiac disease

Date: February 23, 2018, Source: American Society for Biochemistry and Molecular Biology (web link)

[2] Oral Manifestations of Celiac Disease and Wheat Allergy: Report of Three Cases and Review of Literature

Oreamuno YV, BSND MF. Oral Manifestations of Celiac Disease and Wheat Allergy: Report of Three Cases and Review of Literature. Odovtos-International Journal of Dental Sciences.:55-67. (web link)

[3] Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study

Liu PH, Lebwohl B, Burke KE, Ivey KL, Ananthakrishnan AN, Lochhead P, Olen O, Ludvigsson JF, Richter JM, Chan AT, Khalili H. Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study. The American Journal of Gastroenterology. 2018 Sep 4:1. (web link)

[4] The Nutritional and Social Contexts of Celiac Disease in Women: A Qualitative Study.

Rodríguez-Almagro J, Rodríguez-Almagro D, Solano-Ruiz M, Siles-González J, Hernández-Martinez A. The Nutritional and Social Contexts of Celiac Disease in Women: A Qualitative Study. The journal of nursing research: JNR. 2018 Aug. (web link)

[5] PHARMACOGENOMICS OPEN A NEW GATE WAY IN THE TREATMENT OF CELIAC DISEASE

SOMIA GUL1*, ABEEHA MALICK1, SAMEERA KALEEM1 AND ANIQA MALICK2

1Faculty of Pharmacy, Jinnah University for Women, Pakistan.

2Faculty of Pharmacy, University of Karachi, Pakistan. (web link)

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