News Update on Chromosome Research: Aug – 2019

Capturing Chromosome Conformation

We describe AN approach to observe the frequency of interaction between any 2 genomic loci. Generation of a matrix of interaction frequencies between sites on an equivalent or completely different chromosomes reveals their relative spacial disposition and provides data regarding the physical properties of the body substance fiber. this system may be applied to the spacial organization of entire genomes in organisms from microorganism to human. victimization the yeast brewer’s yeast, we tend to might ensure best-known qualitative options of body organization among the nucleus and dynamic changes in this organization throughout meiosis. [1]

Chromosome atlas of flowering plants.

The first edition of this work, written by Darlington and Janaki Ammal, appeared in 1945 underneath the title body Atlas of Cultivated Plants [see H.A., 15: 2065]. within the gift edition this idea has been extended to incorporate all the flowering plants; it embraces nearly eighteen, 000 species, giving the chromosome range and main uses of every. This huge extension has been achieved, while not creating the book unduly massive, by removing the complete of the first introductory portion. In its part, a separate volume, entitled body phytology, has been created by faculty member Darlington, associated this is an introduction to the Atlas, while being in itself a skilled survey of body behaviour and evolution. [2]

Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants

A number of people with aberrant Y chromosomes are tested for the presence of Y-chromosome-specific reiterated deoxyribonucleic acid. These studies find Y-chromosome-specific reiterated sequences on the long arm of the Y chromosome. Correlation with makeup and different noted Y chromosome markers establish that the Y-chromosome-specific reiterated deoxyribonucleic acid mentioned here has no evident role in male determination. [3]

An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome

Patients with myeloma (MM) accumulate adverse copy range aberrations (CNAs), gains of 1q21, and 17p deletions throughout unwellness progression. A set of those patients develops heightened 1q12 pericentromeric instability and jumping translocations of 1q12 (JT1q12), proved  by inflated copy CNAs of 1q21 and losses in receptor chromosomes (RC). to grasp the progression of those aberrations we have a tendency to analyzed metaphase cells of fifty patients with ≥4 CNAs of 1q21 by G-banding, locus specific FISH, and spectral karyotyping. In eight patients with ≥5 CNAs of 1q21 we have a tendency to known a body instability constitution just like that found in ICF syndrome (immunodeficiency, body structure instability, and facial anomalies). [4]

Amanita Phalloides Avoids Tumor Growth of Leukocytes with Philadelphia Chromosome: Case Report

Background: Treatment failure in patients United Nations agency have chronic chronic leukemia (CML) victimization aminoalkanoic acid enzyme inhibitors is common thanks to development of secondary mutations. death angel (Amanita) contains low dose of alpha-amanitin (amanitin),which inhibitis RNA enzyme II (RNAP) resulting in swiftness down of the expansion of tumour cells while not poignant traditional cells.

Aim: to work out if Amanita inhibits the expansion of urban center body (Ph1) carrying leukocytes in CML. [5]

Reference

[1] Dekker, J., Rippe, K., Dekker, M. and Kleckner, N., 2002. Capturing chromosome conformation. science, 295(5558), pp.1306-1311. (Web Link)

[2] Darlington, C.D. and Wylie, A.P., 1956. Chromosome atlas of flowering plants. Chromosome atlas of flowering plants. (Web Link)

[3] Kunkel, L.M., Smith, K.D., Boyer, S.H., Borgaonkar, D.S., Wachtel, S.S., Miller, O.J., Breg, W.R., Jones, H.W. and Rary, J.M., 1977. Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants. Proceedings of the National Academy of Sciences, 74(3), pp.1245-1249. (Web Link)

[4] An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome
Jeffrey R. Sawyer, Erming Tian, Brian A. Walker, Christopher Wardell, Janet L. Lukacs, Gael Sammartino, Clyde Bailey, Carolina D. Schinke, Sharmilan Thanendrarajan, Faith E. Davies, Gareth J. Morgan, Bart Barlogie, Maurizio Zangari & Frits van Rhee
Blood Cancer Journalvolume 9, Article number: 62 (2019) (Web Link)

[5] Riede, I. (2017) “Amanita Phalloides Avoids Tumor Growth of Leukocytes with Philadelphia Chromosome: Case Report”, International Journal of Medical and Pharmaceutical Case Reports, 10(3), pp. 1-7. doi: 10.9734/IJMPCR/2017/38205. (Web Link)

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