News Update on Anemia Research: Jan – 2020

Anemia of Chronic Disease

New therapeutic strategies have emerged along side our understanding that disturbances of iron homeostasis, impaired proliferation of erythroid progenitor cells, and blunted erythropoietin response occur in anemia of chronic disease. This review discusses advances in our knowledge of the causes and management of the condition. [1]

Autoimmune hemolytic anemia

Red blood corpuscle (RBC) autoantibodies are a comparatively uncommon explanation for anemia. However, autoimmune haemolytic anaemia (AIHA) must be considered within the medical diagnosis of hemolytic anemias, especially if the patient features a concomitant lymphoproliferative disorder, autoimmune disorder , or viral or mycoplasmal infection. Classifications of AIHA include warm AIHA, cold agglutinin syndrome, paroxysmal cold hemoglobinuria, mixed‐type AIHA, and drug‐induced AIHA. Characteristics of the autoantibodies are liable for the varied clinical entities. As a result, diagnosis is predicated on the clinical presentation and a serologic work‐up. for every classification of AIHA, this review discusses the demographics, etiology, clinical presentation, laboratory evaluation, and treatment options. Am. J. Hematol. [2]

Iron Deficiency Anemia

The prevalence of iron deficiency anemia is 2 percent in adult men, 9 to 12 percent in non-Hispanic white women, and nearly 20 percent in black and Mexican-American women. Nine percent of patients older than 65 years with iron deficiency anemia have a gastrointestinal cancer when evaluated. The U.S. Preventive Services Task Force currently recommends screening for iron deficiency anemia in pregnant women but not in other groups. Routine iron supplementation is suggested for high-risk infants six to 12 months aged . Iron deficiency anemia is classically described as a microcytic anaemia . The medical diagnosis includes thalassemia, sideroblastic anemias, some sorts of anemia of chronic disease, and plumbism. [3]

Association between anemia and hyperuricemia: results from the Korean National Health and Nutrition Examination Survey

Hyperuricemia and anemia share several comorbidities, but the association between the 2 conditions remains unclear. the aim of this study was to research the association between hyperuricemia and anemia. Data of 10794 subjects from the Korean National Health and Nutrition Examination Survey conducted in 2016–2017 were analyzed using multivariate logistic regression analyses. An association between anemia and hyperuricemia wasn’t evident in subjects without chronic renal disorder (CKD). In patients with CKD, anemia increased the danger of hyperuricemia by 2-fold. This association remained significant when adjusting for the glomerular filtration rate. In subgroup analyses, the association of anemia with hyperuricemia was significant in subjects aged ≥65 years, and in those with diabetes or hypertension. [4]

Management of Odontogenic Abscess in Patients with Sickle Cell Anemia: 5 Case Reports

Sickle cell anemia (SCA) may be a hereditary disorder characterized by a defect within the red blood corpuscle (RBC) hemoglobin molecule leading to a diminished ability for the blood to hold oxygen and a bent for the blood to clump. Clinical manifestations of SCA, aside from the vasoocclusive complications are increasing susceptibility to infection, and chronic anemia from both hemolysis of the sickle cells. Five patients with age starting from 14 to 27 years; presented to the service of Dentistry, Mixed Medicine Center and SS Anemia (MMCSA), Kinshasa/DR. Congo with a history of pain and swelling within the mandible and/or maxillary regions of several days duration. All 5 patients were diagnosed with odontogenic abscesses. Because any infection during a patient with SS disease can become life-threatening, we present these case reports to signalize to the present significant issue and share our clinical management and knowledge , especially with surgeons who practice in areas with limited resources. [5]

Reference

[1] Weiss, G. and Goodnough, L.T., 2005. Anemia of chronic disease. New England Journal of Medicine, 352(10), (Web Link)

[2] Gehrs, B.C. and Friedberg, R.C., 2002. Autoimmune hemolytic anemia. American journal of hematology, 69(4), (Web Link)

[3] Killip, S., Bennett, J.M. and Chambers, M.D., 2007. Iron deficiency anemia. American family physician, 75(5), (Web Link)

[4] Association between anemia and hyperuricemia: results from the Korean National Health and Nutrition Examination Survey
Yeonghee Eun, Kyung-Do Han, Da Hye Kim, In Young Kim, Eun-Jung Park, Seulkee Lee, Hoon-Suk Cha, Eun-Mi Koh, Jaejoon Lee & Hyungjin Kim
Scientific Reports volume 9, (Web Link)

[5] Alphonse, M., Fidele, N., Dany, K., Olivier, N., Augustin, M. and Rubina, S. (2017) “Management of Odontogenic Abscess in Patients with Sickle Cell Anemia: 5 Case Reports”, Journal of Advances in Medicine and Medical Research, 20(6), (Web Link)

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