Latest Research on Tablets: April 21

[1] Vindolanda tablets

The Latin writing tablets from Vindolanda, a Roman auxiliary fort about a mile south of Hadrian’s Wall, were discovered by the archaeologist R. E. Birley in excavations of parts of the pre‐Hadrianic timber forts during the period 1974–2004.

[2] Orally Disintegrating Tablets: A Review

Drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and biochemical parameters pertinent to their performance. Over the past three decades, orally disintegrating tablets (ODTs) have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. ODTs are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. Products of ODT technologies entered the market in the 1980s, have grown steadily in demand, and their product pipelines are rapidly expanding. New ODT technologies address many pharmaceutical and patient needs, ranging from enhanced life-cycle management to convenient dosing for paediatric, geriatric, and psychiatric patients with dysphagia.

[3] ORODISPERSIBLE TABLETS: AN OVERVIEW

Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop orally disintegrating tablets (ODTs) with improved patient compliance and convenience. ODTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. Orally disintegrating tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules.This review describes the various formulation aspects, disintegrants employed and technologies developed for ODTs, along with various excipients, evaluation tests, marketed formulations, and drugs explored in this field.

[4] Spectrophotometric Estimation of Cilnidipine in Tablets

Aim: The paper discusses the Spectrophotometric method developed to determine Cilnidipine in pharmaceutical formulation.

Methodology: The method depends on the reaction of the nitro group of the drug with Potassium Hydroxide in Dimethyl Sulphoxide (DMSO) medium to form a coloured product, which shows maximum absorbance at 425 nm. It also Common excipents used in the formulation bear no effect on the proposed method. The authenticity and performance of the proposed method is approved by point and interval hypothesis tests and through recovery studies.

Results: The linear regression equations obtained by applying least square regression analysis for Cilnidipine were r2= 0.9997 and adheres Beer’s Law in the concentration range of 1– 9 μg/ml.

Conclusion: The method was validated for specificity, linearity, accuracy, precision, Limit of detection and limit of quantification are found to be suitable to be employed in Quality Control as per the International Conference on Harmonization guidelines.

[5] Formulation and Evaluation of Sustained Release Matrix Tablets of Metformin Hydrochloride Using pH Dependent and pH Independent Methacrylate Polymers

Metformin hydrochloride is recommended globally as first line therapy due to its favorable profile on morbidity and mortality associated with type-2 diabetes mellitus. However, limitations of multiple dosing and risk of triggering gastrointestinal symptoms make its dose optimization difficult. Extended-release metformin matrix tablets were prepared by direct compression of drug and different pH-dependent (Eudragit L-100 and S-100) and pH-independent (Eudragit RLPO and RSPO) polymer combinations. The influence of varying the polymer/polymer (w/w) ratio was evaluated. Among the different examined polymer blends, matrix tablets based on S-100/RLPO and S-100/RSPO mixtures gave the more sustained release pattern. The excipients used in this study did not alter physicochemical properties of the drug, as tested by Fourier transform Infrared Spectroscopy and the thermal analysis using differential scanning calorimetry. All the batches were evaluated for thickness, weight variation, hardness, and drug content uniformity. The in vitro drug dissolution study was carried out using USP 22 apparatus II, paddle method and the release mechanisms were explored. Mean dissolution time is used to characterize drug release rate from a dosage form and indicates the drug release retarding efficiency of polymer. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranges from diffusion controlled to anomalous type. Fitting the data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release.

 

Reference

[1] Bowman, A.K., 2013. Vindolanda tablets. The Encyclopedia of Ancient History.

[2] Hirani, J.J., Rathod, D.A. and Vadalia, K.R., 2009. Orally disintegrating tablets: a review. Tropical journal of pharmaceutical research8(2).

[3] Bandari, S., Mittapalli, R.K. and Gannu, R., 2014. Orodispersible tablets: An overview. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm2(1).

[4] Safhi, M.M., 2015. Spectrophotometric Estimation of Cilnidipine in Tablets. Journal of Pharmaceutical Research International, pp.451-456.

[5] Wadher, K.J., Kakde, R.B. and Umekar, M.J., 2011. Formulation and evaluation of sustained release matrix tablets of metformin hydrochloride using pH dependent and pH independent methacrylate polymers. Journal of Pharmaceutical Research International, pp.29-45.

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