Latest Research on Eye Drop: Dec – 2019

Determinants of eye drop size

Ophthalmic solutions ar accessible for multidose or single-dose administration in an exceedingly wide selection of glass and plastic pipette bottles that deliver drops with a volume between twenty five and seventy μl. From a biopharmaceutical and economic purpose of read, however, smaller volumes of five to fifteen μl ought to be instilled. during this review, the technical, pharmaceutical, and therapeutic aspects of eye drop formation and delivery ar bestowed. the various kinds of containers ar delineated  and therefore the determinants of eye drop size ar mentioned, like the look and physical characteristics of the pipette tip and bottle, the physico-chemical properties of the answer, and therefore the manner during which the patient dispenses the drops. [1]

Cyclodextrins in eye drop formulations: enhanced topical delivery of corticosteroids to the eye

Cyclodextrins ar cylindrical oligosaccharides with a oleophilic central cavity and hydrophilic  outer surface. they’ll kind water‐soluble complexes with oleophilic medication, that ‘hide’ within the cavity. Cyclodextrins may be accustomed kind liquid eye drop solutions with oleophilic medication, like steroids and a few chemical element anhydrase inhibitors. The cyclodextrins increase the water solubility of the drug, enhance drug absorption into the attention, improve liquid stability and cut back native irritation. [2]

Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye

Purpose. to judge the effectiveness of a brand new stuff eye drop containing synthetic resin glycol four hundred and humectant demulcents with hydroxypropyl-guar as a gelling agent (Test Product) to a system with carboxymethylcellulose (Control Product) for reducing dry eye signs and symptoms. Methods. lxxxvii dry eye volunteers were listed at seven sites for this six-week, at the same time controlled, double-masked clinical study. Results. The take a look at Product considerably reduced mucous membrane staining (p = zero.025) and temporal membrane staining (p = zero.024) compared to the management. [3]

Eye drop technique and patient-reported problems in a real-world population of eye drop users

Objective: To assess eye drop technique and patient-reported issues with eye drop instillation in a very medical aid sample of eye drop users.

Methods: Cross-sectional data-based study in 136 community pharmacies in Belgique. Patient inclusion criteria were being age ≥ 18 years and victimization eye drops for ≥ 1 month (to make sure that patients were already at home with eye drop instillation). Participants incontestible their eye drop technique and completed a self-administered form. [4]

Successful Treatment for Methicillinn Resistent Staphylococcus aureus Conjunctivitis Using 1% Povidone Iodine Eye Drop: Two Cases

Purpose: long infirm patients oftentimes gift with refractory chronic inflammation. Multidrug-resistant bacterium, like methicillin-resistant staphylococci aureus (MRSA), square measure usually isolated; infections caused by such bacterium square measure treated with antibiotic drug, though refraining from overuse of this drug is suggested. microorganism resistance to povidone-iodine (PI) has not been observed; thus, it is effectively used for treating microorganism infections. However, it’s not been popularly used for treating ocular surface infections. we have a tendency to report 2 cases of multidrug-resistant microorganism inflammation treated with PI. [5]

Reference

[1] Van Santvliet, L. and Ludwig, A., 2004. Determinants of eye drop size. Survey of ophthalmology, 49(2), (Web Link)

[2] Loftsson, T. and Stefánsson, E., 2002. Cyclodextrins in eye drop formulations: enhanced topical delivery of corticosteroids to the eye. Acta Ophthalmologica Scandinavica, 80(2), (Web Link)

[3] Christensen, M.T., Cohen, S., Rinehart, J., Akers, F., Pemberton, B., Bloomenstein, M., Lesher, M., Kaplan, D., Meadows, D., Meuse, P. and Hearn, C., 2004. Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye. Current eye research, 28(1), (Web Link)

[4] Eye drop technique and patient-reported problems in a real-world population of eye drop users
Els Mehuys, Christophe Delaey, Thierry Christiaens, Luc Van Bortel, Inge Van Tongelen, Jean-Paul Remon & Koen Boussery
Eye (2019) (Web Link)

[5] Matsuura, K., Terasaka, Y., Uotani, R. and Inoue, Y. (2017) “Successful Treatment for Methicillinn Resistent Staphylococcus aureus Conjunctivitis Using 1% Povidone Iodine Eye Drop: Two Cases”, Ophthalmology Research: An International Journal, 7(2), (Web Link)

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