Latest Research News on Lipophilic Research: Sep – 2019

Emulsion‐Based Delivery Systems for Lipophilic Bioactive Components

There is a pressing want for edible delivery systems to encapsulate, protect, and unharness bioactive lipids inside the food, medical, and pharmaceutical industries. the actual fact that these delivery systems should be edible puts constraints on the kind of ingredients and process operations which will be wont to produce them. Emulsion technology is especially fitted to the look and fabrication of delivery systems for encapsulating bioactive lipids. This review provides a quick summary of the main bioactive lipids that require to be delivered inside the food trade (for example, ω‐3 fatty acids, carotenoids, and phytosterols), highlight the most challenges to their current incorporation into foods. [1]

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

Mitochondrial aerophilic harm contributes to a spread of chronic diseases. Consequently, the selective inhibition of mitochondrial aerophilic harm may be a promising therapeutic strategy. a method to try to to this can be to create antioxidants that are by selection accumulated into mitochondria at intervals patients. Such mitochondria-targeted Associate in Nursingtioxidants are developed by conjugating the oleophilic triphenylphosphonium ion to an inhibitor moiety, like ubiquinol or α-tocopherol. These compounds pass simply through all biological membranes, as well as the barrier, and into muscle cells and therefore reach those tissues most laid low with mitochondrial aerophilic harm. [2]

Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

By employing a potential-dependent J-aggregate-forming delocalized oleophilic ion, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine++ + halide (JC-1), we discover that membrane potentials across mitochondria in an exceedingly living cell is heterogeneous. Remarkably, even among an extended contiguous cell organ, regional nonuniformity in membrane potentials seems to be doable. [3]

Lipophilic statins inhibit Zika virus production in Vero cells

Zika virus (ZIKV) may be a mosquito-borne member of the arborvirus family. ZIKV infection has been related to medical specialty complications like microcephalus in newborns and Guillain-Barre syndrome in adults; therefore, therapeutic agents are desperately required. Statins are clinically approved for lowering sterol levels to forestall disorder however have shown potential as antiviral medicine. during this study, we tend to explored the likelihood of utilizing statins as anti-ZIKV medicine. [4]

Insights on Fatty Acids in Lipophilic Prodrug Strategy

Aim: This review is devoted to fatty acids importance in prodrugs development strategy. numerous ways of fatty acid-linked prodrugs ar mentioned within the article.

Summary: The exaggerated drug lipophilicity is of nice significance in each blood and body fluid delivery, because the most fascinating physical issue for the desired drug forms. exaggerated lipophilicity will prolong the action of the drug and enhance drug passive diffusion thorough the biological barriers like skin, gi epithelial tissue and barrier. [5]

Reference

[1] McClements, D.J., Decker, E.A. and Weiss, J., 2007. Emulsion‐based delivery systems for lipophilic bioactive components. Journal of food science, 72(8), (Web Link)

[2] Murphy, M.P. and Smith, R.A., 2007. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu. Rev. Pharmacol. Toxicol., 47, (Web Link)

[3] Smiley, S.T., Reers, M., Mottola-Hartshorn, C., Lin, M., Chen, A., Smith, T.W., Steele, G.D. and Chen, L.B., 1991. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proceedings of the National Academy of Sciences, 88(9), (Web Link)

[4] Lipophilic statins inhibit Zika virus production in Vero cells
Erica Españo, Jeong-Hyun Nam, Eun-Jung Song, Daesub Song, Chong-Kil Lee & Jeong-Ki Kim
Scientific Reportsvolume 9, Article number: 11461 (2019) (Web Link)

[5] Dąbrowska-Maś, E. (2017) “Insights on Fatty Acids in Lipophilic Prodrug Strategy”, International Research Journal of Pure and Applied Chemistry, 14(4), (Web Link)

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