Latest Research News on Hypoglycemia Research: Sep – 2019

Hypoglycemia in Diabetes

Iatrogenic symptom causes perennial morbidity in most of the people with kind one polygenic disease and plenty of with kind a pair of polygenic disease, and it’s generally fatal. The barrier of symptom typically precludes maintenance of euglycemia over a period of time of polygenic disease and so precludes full realization of euglycemia’s semipermanent advantages. whereas the clinical presentation is commonly characteristic, notably for the practiced individual with polygenic disease, the animal tissue and neuroglycopenic symptoms of symptom ar nonspecific and comparatively insensitive; thus, several episodes aren’t recognized. symptom may end up from exogenous or endogenous hypoglycaemic agent excess alone. However, induced symptom is often the results of the interaction of absolute or relative hypoglycaemic agent excess and compromised aldohexose counterregulation in kind one and advanced kind a pair of polygenic disease. [1]

Hypoglycemia: A Potent Stimulus to Secretion of Growth Hormone

In traditional subjects, symptom produces Associate in Nursing abrupt and sustained rise in levels of human internal secretion in plasma. This impact is freelance of hormone, glucagon, or vasoconstrictor. Prolonged fast is in the course of an increase within the secretion level in plasma. activity of this secretion when elicited symptom may be a specific take a look at for pituitary somatotropic operate. [2]

Reduced Neuroendocrine and Symptomatic Responses to Subsequent Hypoglycemia After 1 Episode of Hypoglycemia in Nondiabetic Humans

To test the hypothesis that hypoglycaemia itself causes reduced system and symptomatic responses to ensuant hypoglycemia, we tend to measured those responses throughout clamped hypoglycaemia (2.8 mM) on consecutive mornings on double, with interval afternoon (1400–1600) hypoglycaemia (3 mM) on one occasion and interval afternoon euglycemia (5 mM) on the opposite, in 9 nondiabetic humans. None of the measured responses were reduced by interval euglycemia. In distinction, plasma neurotransmitter (P < zero.005), hormone (P < zero.005), exocrine gland peptide (P < zero.01), corticoid (P < zero.02), and total (P < zero.001), animal tissue (P < zero.001) and neuroglycopenic (P < zero.05) symptom responses to morning hypoglycaemia were reduced when interval afternoon hypoglycemia. [3]

Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids

Tramadol is one among the foremost normally used analgesics worldwide, classified as having a coffee abuse potential by U.S. Drug social control Agency, and sometimes suggested in pain management pointers. Its pain-relieving mechanism of action is attributed to delicate μ-opioid receptor agonism, 5-hydroxytryptamine and monoamine neurotransmitter mediate nociception modulation, and N-methyl-D-aspartate receptor, NMDAR, antagonism. However, recent case reports ANd case-control studies have shown an association between tramadol use and hypoglycaemia. [4]

Clinical Profile of Hypoglycemia in Diabetic Patients: A Prospective Study in a Tertiary Care Hospital

Background: Hypoglycemia refers to a clinical condition resulting from an abnormally low plasma glucose level <40 mg/dl without symptoms and <50 mg/dl with symptoms. Clinically, it is characterized by varying degree of neurological dysfunction and is responsive to the administration of glucose. Hypoglycemia is commonly caused by drugs used to treat diabetes mellitus.

Objective: To study the clinical profile, precipitating factors and outcome in the patients of hypoglycemia.

Materials and Methods: This hospital based 2 years prospective study was conducted in the Department of Medicine, Kasturba Medical College and hospital, Manipal, Karnataka. Clinical profile of 100 diabetic patients on OHA’s or Insulin treatment with the diagnosis of hypoglycemia were analyzed. The criteria for hypoglycemia was blood glucose level of <40mg/dl without symptoms and <50 mg/dl with symptoms. [5]

Reference

[1] Cryer, P.E., Davis, S.N. and Shamoon, H., 2003. Hypoglycemia in diabetes. Diabetes care, 26(6), (Web Link)

[2] Roth, J., Glick, S.M., Yalow, R.S. and Berson, S.A., 1963. Hypoglycemia: a potent stimulus to secretion of growth hormone. Science, 140(3570), (Web Link)

[3] Heller, S.R. and Cryer, P.E., 1991. Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans. Diabetes, 40(2), (Web Link)

[4] Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids
Tigran Makunts, Andrew U, Rabia S. Atayee & Ruben Abagyan
Scientific Reportsvolume 9, Article number: 12490 (2019) (Web Link)

[5] Seth, P., Bery, A. and Kumar Gupta, A. (2018) “Clinical Profile of Hypoglycemia in Diabetic Patients: A Prospective Study in a Tertiary Care Hospital”, Asian Journal of Research in Medical and Pharmaceutical Sciences, 4(1), (Web Link)

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