Latest News on Lymphoma Research: Jan – 2020

Primary central nervous system lymphoma in japan: a nationwide survey

Purpose: to research clinical features, treatment results, and prognostic factors of primary central systema nervosum lymphoma (PCNSL) in Japan, we conducted a nationwide survey.

Methods and Materials: We analyzed 466 patients with histologically proven PCNSL treated between 1985 and 1994 at 62 institutions, including 56 medical schools.

Results: Patient and tumor characteristics of the 466 patients weren’t greatly different from those reported previously, apart from the relatively high proportion of T-cell lymphoma (8.5%). The median survival time of the 466 patients was 18 months, and therefore the 5- and 10-year survival rates were 15.2% and 8.2%, respectively. Complete response was observed in 63% of evaluable patients, but 64% of the entire responders developed recurrence (77% within the irradiated volume). [1]

Non-Hodgkin’s Lymphoma After Primary Hodgkin’s Disease in the German Hodgkin’s Lymphoma Study Group: Incidence, Treatment, and Prognosis

PURPOSE: The cumulative incidence for non-Hodgkin lymphoma’s (NHL) after primary Hodgkin’s disease (HD) ranges between 1% and 6%. to research the course of disease for secondary NHL, we retrospectively analyzed patients treated within clinical trials of the German Hodgkin’s Lymphoma Study Group (GHSG) since 1981.

PATIENTS AND METHODS: From 1981 to 1998, the GHSG conducted three generations of clinical trials for the treatment of primary HD involving a complete of 5,406 patients. Reference histology by an expert panel was obtained for 4,104 of the patients. Data on incidence, treatment, and outcome of secondary NHL were updated in March 1999. [2]

Testicular lymphoma.

Non-Hodgkin’s lymphoma of the testis is an uncommon disease. It accounts for about 9% of testicular neoplasms. Despite this low overall incidence, however, it’s the foremost common testicular malignancy within the elderly. Testicular lymphoma features a rather high incidence of bilateral involvement and a propensity for extranodal spread to the skin, subcutaneous tissue, CNS, lung, and Waldeyer’s ring. Although intermediate-grade diffuse large B-cell lymphoma is that the commonest histologic pattern among primary testicular lymphoma, secondary infiltration of the testis, especially in high-grade Burkitt’s lymphoma, is more prevalent. Although excellent results with a doxorubicin-containing chemotherapy regimen are achieved in early-stage disease, patients with advanced disease have a grave prognosis. [3]

Diagnostic utility of STAT6YE361 expression in classical Hodgkin lymphoma and related entities

Although the excellence of classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma using morphology and immunostains is simple in most instances, occasional cases pose diagnostic challenge. We sought to work out the utility of the novel YE361 STAT6 rabbit antibody in Hodgkin lymphoma and diagnostically challenging B- and T-cell non-Hodgkin lymphoma entities with Hodgkin-like features. Cases from seven institutions included: 57 classical Hodgkin lymphomas (31% EBV+), 34 nodular lymphocyte predominant Hodgkin lymphomas, 34 mimicking B- and T-cell non-Hodgkin lymphomas, and seven reactive lymphoproliferations. [4]

A Rare Case Report of Duodenal Marginal Zone B-cell Lymphoma Related to Immunoproliferative Small Intestinal Disease and Associated Lymphoma (IPSID)

Marginal zone B-cell lymphoma may be a unique lymphoma of the alimentary canal most ordinarily in developing countries with poor socioeconomic conditions, poor hygiene, malnutrition, and a high degree of intestinal infections where IPSID is common.

We experienced a rare case of extranodal MZBCL in duodenum (sub sort of MALT) during a 14-year-old girl who complained of epigastric pain.

Abdominal computerized tomography (CT) with Intravenous (IV) contrast showed mixed mass infiltrate the intestinal wall with mesenteric lymphadenopathy.

Upper alimentary canal endoscopy had showed obstruction within the 2nd segment of duodenum, biopsies were taken. [5]

Reference

[1] Hayabuchi, N., Shibamoto, Y., Onizuka, Y. and Members, J.C.L.S.G., 1999. Primary central nervous system lymphoma in Japan: a nationwide survey. International Journal of Radiation Oncology* Biology* Physics, 44(2), (Web Link)

[2] Rueffer, U., Josting, A., Franklin, J., May, M., Sieber, M., Breuer, K., Engert, A. and Diehl for the German Hodgkin’s Lymphoma Study Group, V., 2001. Non-Hodgkin’s lymphoma after primary Hodgkin’s disease in the German Hodgkin’s Lymphoma Study Group: incidence, treatment, and prognosis. Journal of clinical oncology, 19(7), (Web Link)

[3] Shahab, N. and Doll, D.C., 1999, June. Testicular lymphoma. In Seminars in oncology (Web Link)

[4] Diagnostic utility of STAT6YE361 expression in classical Hodgkin lymphoma and related entities
Charles Van Slambrouck, Jooryung Huh, Cheolwon Suh, Joo Y. Song, Madhu P. Menon, Aliyah R. Sohani, Amy S. Duffield, Reva C. Goldberg, Paola Dama, Kazuma Kiyotani, James Godfrey, Carrie Fitzpatrick, Justin Kline, Sonali M. Smith, Elaine S. Jaffe, Sylvia Hartmann & Girish Venkataraman
Modern Pathology (2019) (Web Link)

[5] Aljarad, Z., Nasser, M., Ghazal, A., Alkhaled, M., Obeed, B., Shaghaleh, M. and Alhussein, M. W. (2017) “A Rare Case Report of Duodenal Marginal Zone B-cell Lymphoma Related to Immunoproliferative Small Intestinal Disease and Associated Lymphoma (IPSID)”, Journal of Advances in Medicine and Medical Research, 20(8), (Web Link)

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