Latest News on Dosage Form Research: Oct – 2019

Drug‐delivery Products and the Zydis Fast‐dissolving Dosage Form

Many patients notice it troublesome to swallow tablets and exhausting gelatin capsules and don’t take their medication as prescribed. it’s calculable that fifty of the population is stricken by this downside which ends up during a high incidence of non‐compliance and ineffective medical care. the problem is knowledgeable above all by medical specialty and geriatric patients, however it conjointly applies to UN agency|people that|folks that|those that|those who} ar sick in bed and to those active operating patients who ar busy or movement, particularly people who haven’t any access to water. Such issues will be resolved by means that of the Zydis indefinite quantity kind that doesn’t need water to help swallowing. The Zydis fast‐dissolving indefinite quantity kind may be a distinctive freeze dried healthful pill, made of accepted and acceptable materials. [1]

Drug polymorphism and dosage form design: a practical perspective

Formulators are charged with the responsibility to formulate a product that is physically and with chemicals stable, manufacturable, and bioavailable. Most medicine exhibit structural polymorphism, and it’s desirable to develop the foremost thermodynamically stable being of the drug to assure duplicatable bioavailability of the merchandise over its time period below a spread of real-world storage conditions. There are occasional things during which the event of a stability crystalline or amorphous type is even as a result of a medical profit is achieved. Such things embrace those during which a quicker dissolution rate or higher concentration are desired, so as to attain fast absorption and effectualness, or to attain acceptable general exposure for a low-solubility drug. [2]

Liposomes – a selective drug delivery system for the topical route of administration I. Lotion dosage form

The relevance of liposomes as drug carriers for the topical route of administration was investigated mistreatment Aristopak as a model drug. The liposomal encapsulation favorably altered the drug dipposition; the concentration of the drug faded at the positioning of its adverse effects and raised at the positioning wherever its activity is desired. [3]

Scalable Gastric Resident Systems for Veterinary Application

Gastric resident indefinite quantity forms are used with success in sheep for the delivery of a spread of medication serving to address the challenge of extended dosing. Despite these advances, there remains a major challenge across the vary of species with massive variation in body size. to deal with this, we have a tendency to investigate a ascendible stomachal resident platform capable of prolonged retention. we have a tendency to investigate prototypes in dimensions in keeping with administration and retention within the stomachs of 2 species (rabbit and pig). we have a tendency to investigate sustained stomachal retention of our ascendible indefinite quantity kind platform, and in pigs show the capability to modulate drug unleash mechanics of a model drug in veterinary apply, meloxicam, with our indefinite quantity kind. [4]

Stability Indicating RP-HPLC Method Development and Validation for the Estimation of Atezolizumab in Bulk and Its Injectable Dosage Form

Aim: a brand new straightforward reversed section high performance liquid chromatographical methodology was developed for the estimation of Atezolizumab in bulk and its injectable formulation.

Study Design: Quantitative and qualitative estimation and degradation studies of AZM by mistreatment Rp-HPLC.

Place and period of Study: The work was performed at Santhiram faculty of Pharmacy and duration of study among three months.

Methodology: the strategy was developed and valid and higher results were obtained by mistreatment polar star C18-A (150 mm—4.6 mm i.d., 5µm particle size column by mistreatment mobile section zero.1% TFA in acetonitrile: water 90:10 v/v. The mobile section rate of flow was fastened zero.75 mL/min. [5]

Reference

[1] Seager, H., 1998. Drug‐delivery products and the Zydis fast‐dissolving dosage form. Journal of pharmacy and pharmacology, 50(4), (Web Link)

[2] Singhal, D. and Curatolo, W., 2004. Drug polymorphism and dosage form design: a practical perspective. Advanced drug delivery reviews, 56(3), (Web Link)

[3] Mezei, M. and Gulasekharam, V., 1980. Liposomes-a selective drug delivery system for the topical route of administration I. Lotion dosage form. Life Sciences, 26(18), (Web Link)

[4] Scalable Gastric Resident Systems for Veterinary Application
Alison Hayward, Taylor Bensel, Hormoz Mazdiyasni, Jaimie Rogner, Ameya R. Kirtane, Young-Ah Lucy Lee, Tiffany Hua, Ambika Bajpayee, Joy Collins, Shane McDonnell, Cody Cleveland, Aaron Lopes, Aniket Wahane, Robert Langer & Giovanni Traverso
Scientific Reportsvolume 8, Article number: 11816 (2018) (Web Link)

[5] Babu, D. C., Chetty, C. M. and Mastanamma, S. (2017) “Stability Indicating RP-HPLC Method Development and Validation for the Estimation of Atezolizumab in Bulk and Its Injectable Dosage Form”, Journal of Pharmaceutical Research International, 18(5), (Web Link)

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